FAT Family


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Family 9.B.17 - The Putative Fatty Acid Transporter (FAT) Family

Family ID: 52662

The FAT family includes hundreds of sequenced homologues which include fatty acyl CoA ligases (fatty acyl
CoA synthases), carnitine CoA ligases, and putative transporters (Hirsch, et al., 1998). Animals have numerous paralogues, and yeast and bacteria also exhibit paralogues. These proteins exhibit 2-4 TMSs and are 500-600 residues long. While some of the eukaryotic members of the family have been shown to increase the uptake of long chain fatty acids when expressed in mammalian cells, a Mycobacterium tuberculosis homologue increases the rate of uptake of long chain fatty acids when expressed in E. coli. It is not clear whether these proteins actually catalyze transport, or merely function to trap fatty acids in the cell cytoplasm as a result of covalent modification.

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	Arabidopsis Families
	At3g48990 4-coumarate-CoA ligase -like protein At1g20560 expressed protein At1g20510 expressed protein At3g21240 putative 4-coumarate:CoA ligase 2 At1g66120 AMP-binding enzyme, putative At5g38120 4-coumarate--CoA ligase -like protein At4g19010 4-coumarate--CoA ligase At1g20500 hypothetical protein At5g63380 4-coumarate--CoA ligase At1g65060 4-coumarate--CoA ligase 3 At1g65890 AMP-binding enzyme, putative At3g21230 4-coumarate--CoA ligase 2		At1g65880 AMP-binding enzyme, putative At1g20490 hypothetical protein At1g51680 4-coumarate:CoA ligase 1 At2g17650 hypothetical protein At1g21540 AMP-binding enzyme, putative At1g21530 AMP-binding enzyme, putative At1g62940 4-coumarate--CoA ligase At1g77240 AMP-binding enzyme, putative At1g30520 hypothetical protein At4g05160 4-coumarate--CoA ligase At1g76290 AMP-binding enzyme, putative
	Yeast Families
	YBR041W FAT1 Long-chain fatty acid transporter YBR222C FAT2 peroxisomal-coenzyme A synthease YAL054C ACS1 acetyl-coenzyme A synthease 1 YLR153C ACS2 acetyl-coenzyme A synthease 2
	Rice Families (Coming Soon!)

A distributed project investigating gene networks that control uptake and accumulation of plant nutrients and toxic metals. Funded by the plant genome program of the National Science Foundation (DBI-0077378). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.

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