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Family 2.A.37 - The Monovalent Cation:Proton Antiporter-2 Family
Family ID: 52632
The CPA2 family is a moderately large family (over 100 sequenced
members) from bacteria, archaea and eukaryotes. Among the functionally
well-characterized members of the family are (1) the KefB/KefC
K+ efflux proteins of E. coli which may be capable of catalyzing
both K+/H+ antiport and K+ uniport, depending on conditions (Bakker
et al., 1987; Booth et al., 1996; Munro et al., 1991), (2) the
Na+/H+ antiporter of Enterococcus hirae(Waser et al., 1992) and
(3) the K+/H+ antiporter of S. cerevisiae. It has been proposed
that under normal physiological conditions, these proteins may
function by essentially the same mechanism (Reizer et al., 1992).
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Mäser
P, Thomine S, Schroeder JI, Ward JM, Hirschi K, Sze H, Talke
IN, Amtmann A, Maathuis FJM, Sanders D, Harper JH, Tchieu
J, Gribskov M, Persans MW, Salt DE, Kim SA, Guerinot ML (2001)
Phylogenetic relationships within cation-transporter families
of Arabidopsis thaliana. Plant Physiol 2001 Aug;126(4):1646-67
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