Family 2.A.21 - The Solute:Sodium Symporter Family

Family ID: 52626
Members of the SSS family catalyze solute:Na+ symport. The solutes
transported may be sugars, amino acids, nucleosides, inositols,
vitamins, urea or anions, depending on the system. Members of
the SSS family have been identified in bacteria, archaea and animals,
and all functionally well characterized members catalyze solute
uptake via Na+ symport. The human placental multivitamin symporter
cotransports an anionic vitamin with two Na+. Proteins of the
SSS vary in size from about 400 residues to about 700 residues
and possess twelve to fifteen putative transmembrane helical spanners
(TMSs). They generally share a core of 13 TMSs, but different
members of the family may have different numbers of TMSs