Family 2.A.16 - The Telurite-resistance/Dicarboxylate Transporter Family       

Family ID: 52621

The TDT family includes members from the bacterial (E. coli and Haemophilus influenzae), archaeal (Methanococcus jannaschii) and eukaryotic (Schizosaccharomyces pombe) kingdoms and therefore occurs ubiquitously. Only two members of the family have been functionally characterized. One is the TehA protein of E. coli which functions as a tellurite-resistance uptake permease; the other is the Mae1 protein of S. pombe which functions in the uptake of malate and other dicarboxylates by a proton symport mechanism. These proteins are 320-350 amino acyl residues in length except for the yeast protein which is 438 residues. All exhibit 10 putative transmembrane a-helical spanners (TMSs). The phylogenetic tree for the TDT family exhibits three major branches, one for the bacterial proteins, one for the archaeal proteins and one for the yeast protein.