MFS Family


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Family 2.A.1 - The Major Facilitator Superfamily

Family ID: 52612

The MFS is a very old, large and diverse superfamily that includes over a thousand sequenced members. They catalyze uniport, solute:cation (H+ or Na+) symport and/or solute:H+ or solute:solute antiport. Most are of 400-600 amino acyl residues in length and possess either 12 or 14 putative transmembrane a-helical spanners. They exhibit specificity for sugars, polyols, drugs, neurotransmitters, Krebs cycle metabolites, phosphorylated glycolytic intermediates, amino acids, peptides, osmolites, iron-siderophores, nucleosides, organic anions, inorganic anions, etc. They are found ubiquitously in all three kingdoms of living organisms. One member of the DHA2 family with 14 spanners, the TetL Me2+ · tetracycline:H+ antiporter of B. subtilis (TC #2.A.1.3.16), which also exhibits monovalent ion antiport activity, can be converted to a monovalent cation (Na+, K+, H+) antiporter with no tetracycline transport activity by deletion of TMSs 7 and 8, the two central and extra TMSs (Jin et al., 2001).

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Pao SS, Paulsen IT, Saier MH Jr.
Major Facilitator Superfamily.
Microbiol Mol Biol Rev. 1998 Mar;62(1):1-34. Review.

Sarah M. Sherson, Georg Hemmann, Graham Wallace, Susan Forbes, Veronique Germain, Ruth Stadler,Nicole Bechtold, Norbert Sauer, and Steven M. Smith.
Monosaccharide/proton symporter AtSTP1 plays a major role in uptake and response of Arabidopsis seeds and seedlings to sugars.
Plant J.2000 Dec;24(6):849-57.

Mudge SR, Rae AL, Diatloff E, Smith FW.
Expression analysis suggests novel roles for members of the Pht1 family of phosphate transporters in Arabidopsis.
Plant J. 2002 Aug;31(3):341-53.

	Arabidopsis Families
	2.A.1.1 Sugar Porter (SP) Family At1g11260 STP1 monosaccharide transporter At1g07340 STP2 monosaccharide transporter At5g61520 STP3 monosaccharide transporter At3g19930 STP4 monosaccharide transporter At1g34580 STP5 monosaccharide transporter At3g05960 STP6 monosaccharide transporter At4g02050 STP7 monosaccharide transporter At5g26250 STP8 monosaccharide transporter At1g50310 STP9 monosaccharide transporter At3g19940 STP10 monosaccharide transporter At5g23270 STP11 monosaccharide transporter At4g21480 STP12 monosaccharide transporter At5g26340 STP13 monosaccharide transporter At1g77210 STP14 monosaccharide transporter 2.A.1.9 Phosphate:H+ Symporter Family At5g43350 AtPht1;1 phosphate transporter At5g43370 AtPht1;2 phosphate transporter At5g43360 AtPht1;3 phosphate transporter At2g38940 Atpht1;4 phosphate transporter At2g32830 AtPht1;5 phosphate transporter At5g43340 AtPht1;6 phosphate transporter At3g54700 AtPht1;7 phosphate transport protein At1g20860 AtPht1;8 phosphate transporter protein At1g76430 AtPht1;9 phosphate transporter 2.A.1.8 Nitrate/Nitrite Porter (NNP) Family At1g08090 NRT2;1 high-affinity nitrate transporter At1g08100 NRT2;2 high-affinity nitrate transporter		Unknown Subfamilies At5g60770 high-affinity nitrate transporter ACH1 - like protein At5g60780 high affinity nitrate transporter protein - like At3g45060 high-affinity nitrate transporter - like protein At1g12940 nitrate transporter, putative At5g14570 high affinity nitrate transporter - like protein At1g08930 ERD6 early dehydration-induced protein At1g08920 putative sugar transport protein, ERD6 At5g27360 sugar transporter-like protein At5g27350 sugar transporter-like protein At3g05160 putative sugar transporter At3g05400 sugar transporter, putative At2g48020 putative sugar transporter At3g20460 sugar transporter, putative At5g18840 sugar transporter - like protein At1g75220 integral membrane protein, putative At1g19450 integral membrane protein, putative At3g05150 putative sugar transporter At1g05030 putative sugar transporter protein At1g08890 putative sugar transport protein, ERD6 At1g08900 putative sugar transport protein, ERD6 At1g16370 putative transport protein At1g16390 putative transport protein At1g20840 putative sugar transporter protein At1g30220 hypothetical protein At1g30560 hypothetical protein At1g54730 hypothetical protein At1g67300 putative transport protein At1g73220 putative transporter At1g79360 hypothetical protein At1g79410 hypothetical protein At1g79820 putative sugar transporter At2g16120 putative sugar transporter At2g16130 putative sugar transporter At2g18480 putative sugar transporter At2g20780 putative sugar transporter At2g29650 Na+-dependent inorganic phosphate cotransporter At2g35740 putative sugar transporter At2g38060 Na+-dependent inorganic phosphate cotransporter At2g43330 putative membrane transporter At3g03090 hypothetical protein At3g13050 putative transporter At3g18830 sugar transport, putative At3g20660 hypothetical protein At3g43790 transporter-like protein At3g46980 putative protein At3g47420 putative protein At3g51490 sugar transporter-like protein At4g00370 hypothetical protein At4g04750 putative sugar transporter At4g04760 putative sugar transporter At4g16480 membrane transporter like protein At4g17550 putative protein At4g25220 putative protein At4g35300 putative sugar transporter protein At4g36670 sugar transporter like protein At5g13750 transporter-like protein At5g16150 sugar transporter-like protein At5g17010 sugar transporter - like protein At5g20380 putative protein At5g44370 Na+-dependent inorganic phosphate cotransporter At5g59250 D-xylose-H+ symporter - like protein
	Yeast Families
	2.A.1.1 Sugar Porter (SP) Family YHR094C HXT1 low affinity hexose facilitator YMR011W HXT2 hexose facilitator YDR345C HXT3 low affinity hexose facilitator YHR092C HXT4 low affinity hexose facilitator YHR096C HXT5 hexose transporter YDR343C HXT6 hexose transporter YDR342C HXT7 hexose transporter YJL214W HXT8 hexose transporter YJL219W HXT9 hexose transporter YFL011W HXT10 hexose transporter YOL156W HXT11 hexose transporter YIL170W HXT12 hexose transporter YEL069C HXT13 hexose transporter YNL318C HXT14 hexose transporter YDL245C HXT15 hexose transporter YJR158W HXT16 hexose transporter YNR072W HXT17 hexose transporter YLR081W GAL2 galactose permease YDL194W SNF3 sensor of low glucose conc YDL138W RGT2 sensor of low glucose conc YBR298C MAL61 maltose permease YDL247W YDL247W maltose transporter YJR160C YJR160C maltose transporter YGR289C AGT1 alpha glucoside permease YGL104C YGL104C sugar transporter YBR241C YBR241C sugar transporter YDL199C YDL199C sugar transporter YFL040W YFL040W sugar transporter YDR497C ITR1 inositol permease YOL103W ITR2 inositol permease YDR387C YDR387C sugar transporter YDR536W STL1 sugar transporter 2.A.1.9 Phosphate: H+ Symporter (PHS) Family YCR098C GIT1 glycerolphosphoinositol transporter YML123C PHO84 phosphate / H+ symporter 2.A.1.12 The Sialate: H+ Symporter (SHS) Family YKL217W JEN1 lactate and pyruvate permease 2.A.1.13 Monocarboxylate Porter (MCP) Family YDL054C MCH1 unknown protein YKL221W MCH2 unknown protein YNL125C MCH3 monocarboxylate transporter YOL119C MCH4 putative protein YOR306C MCH5 putative protien		2.A.1.2 The Drug:H+ Antiporter-1 (DHA1) Family YLL028W TPO1 proposed vacuolar polyamine transporter YGR138C TPO2 proposed vacuolar polyamine transporter YPR156C TPO3 proposed vacuolar polyamine transporter YOR378W TPO4 proposed vacuolar polyamine transporter YHR048W YHR048W putative substrate-H+ transporter YBR008C FLR1 putative H+ antiporter YIL120W QDR1 putative substrate-H+ transporter YIL121W YIL121W putative substrate-H+ transporter YNL065W AQR1 acids and quinidine resistance protein YBR180W DTR1 bisformyl dityrosine-H+ antiporter YBR043C YBR043C putative substrate-H+ transporter YJR124C YJR124C putative substrate-H+ transporter YNR055C HOL1 putative substrate-H+ transporter YDR119W YDR119W putative substrate-H+ transporter YCR023C YCR023C putative substrate-H+ transporter YJL163C YJL163C putative substrate-H+ transporter 2.A.1.3 The Drug:H+ Antiporter-2 (DHA2) Family YPR198W SGE1 putative substrate-H+ transporter YGR224W AZR1 putative substrate-H+ transporter YKR105C YKR105C putative substrate-H+ transporter YCL069W YCL069W putative substrate-H+ transporter YMR088C YMR088C putative substrate-H+ transporter YBR293W YBR293W putative substrate-H+ transporter YML116W ATR1 putative substrate-H+ transporter YMR279C YMR279C putative substrate-H+ transporter 2.A.1.14 The Anion:Cation Symporter (ACS) Family YJR152W DAL5 allantoate and ureidosuccinate permease YGR065C VHT1 biotin permease YCR028C FMS1 suppersor of fennpropimorph resistance YGR260W TNA1 nicotinic acid permease YAL067C SEO1 similar to diverse carboxylic acid permeases YIL166C YIL166C similar to diverse carboxylic acid permeases YOL163W YOL163W diverse carboxylic acid permeases YLR004C YLR004C diverse carboxylic acid permeases YLL055W YLL055W diverse carboxylic acid permeases 2.A.1.21 The Drug:H+ Antiporter-3 (DHA3) Family YEL065W SIT1 transport of bacterial sidrophore ferrioxamine B YOL158C ENB1 transporter of sidrophore enterobactin YHL040C ARN1 transporter of ferrirubin and ferrirhodin YHL047C ARN2 transport of sidrophore triacetylfusarinine C YCL073C YCL073C putative substrate:H+ antiporter YKR106W YKR106W putative substrate:H+ antiporter
	Rice Families (Coming Soon!)

A distributed project investigating gene networks that control uptake and accumulation of plant nutrients and toxic metals. Funded by the plant genome program of the National Science Foundation (DBI-0077378). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.

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